Usage of which drug is likely to create disconnection from one's body?

The drug that is most likely to create a disconnection from one's body is PCP, also known as phencyclidine. PCP is a dissociative anesthetic, meaning it can lead to feelings of detachment from reality, self, and one's surroundings. Users may experience a sense of distortion in their perceptions, which can make them feel as though they are floating above their bodies or observing themselves from a distance. This sensation of disconnection is particularly pronounced with PCP, as it interacts with the brain's neurotransmitter systems to produce these disruptive effects.

While other substances on the list can alter perception or mood, they do not typically result in the same level of dissociative experiences as PCP. For example, MDMA, while it can induce feelings of euphoria and emotional connection, doesn't usually create the profound dissociation associated with PCP. Cocaine is primarily a stimulant that increases energy and alertness but does not inherently produce disconnection from the body. Marijuana may lead to altered perception and relaxation, but the dissociative effects are not as strong as those caused by PCP. Therefore, PCP stands out as the drug most likely to create such a disconnection.