Amphetamines primarily affect which neurotransmitter in the brain?

Amphetamines primarily affect the neurotransmitter dopamine in the brain. They increase the release and block the reuptake of dopamine, which enhances its availability in the synaptic cleft. This action contributes to the stimulant effects associated with amphetamines, such as increased alertness, heightened mood, and enhanced concentration.

Dopamine is a key neurotransmitter involved in the brain's reward system, and its modulation by amphetamines plays a significant role in their potential for addiction and euphoria. Understanding the role of dopamine can provide insight into both the therapeutic uses and the risks associated with amphetamine usage, including the development of dependency.

While amphetamines do interact with other neurotransmitters, such as norepinephrine and serotonin, their primary and most significant effect is related to dopamine. This specificity underscores the importance of dopamine in the stimulant effects and overall pharmacological profile of amphetamines.